GLENDALE – As the Arizona Cardinals gear up for their Thursday night matchup against the Seattle Seahawks, what are the top three things to look out for in their primetime matchup?
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Sep 21, 2025; Santa Clara, California, USA; Arizona Cardinals safety Dadrion Taylor-Demerson (42) reacts with teammates after an interception against the San Francisco 49ers during the second half at Levi’s Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Seattle is coming off a dominant 44-12 victory over the New Orleans Saints, and their offense is looking in sync. One of the major things that the Cardinals need to focus on is taking away their explosive offense by shining the spotlight on players like WR Jaxon Smith-Njigba. Arizona will have to avoid going down early, as the last three weeks have shown that its offense is still working through some instability issues.
Sep 21, 2025; Santa Clara, California, USA; Arizona Cardinals running back Trey Benson (33) carries the ball as San Francisco 49ers safety Jason Pinnock (25) defends during the second half at Levi’s Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Getting the run game going will be paramount after the loss of Cards RB James Conner. After Conner’s season-ending injury, Trey Benson has now taken over the first-string running back duties, though that can’t be the only way to attack. Utilizing Emari Demercado in certain packages will be key to opening up this offense and creating a diverse outlook for their run game. Having the offensive line create those holes for Benson and Demercado will be absolutely paramount if they want to be able to open up the rest of their offense.
Dec 8, 2024; Glendale, Arizona, USA; Arizona Cardinals wide receiver Marvin Harrison Jr. (18) cannot make a catch against the Seattle Seahawks during the second half at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images
Having above-average wide receiver play and a strong offensive line is one of the main reasons why Kyler Murray and the Cardinals started the season 10-2 back in 2021. If guys like Marvin Harrison Jr. can step up in crunch time and avoid big mistakes like crucial drops, the Cardinals might find themselves having a big night.
Arizona Cardinals’ offense aims to get on track against Seahawks
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Reporter Benjamin Bliklen covers the Arizona Diamondbacks, Arizona Cardinals, and Phoenix Suns for Burn City Sports. You can follow him on his X account, @BenBliklen
