GLENDALE — The San Francisco 49ers announced that Brock Purdy will start against the Arizona Cardinals on Sunday.
September 28, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) during the third quarter against the Jacksonville Jaguars at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images
49ers coach Kyle Shanahan confirmed Thursday that the Arizona native will be back in action after being sidelined with a right toe injury. Purdy’s return comes at a crucial moment for both San Francisco and Arizona, as the division rivals look to get back in the win column after devastating losses to other NFC West opponents.
Purdy’s consistency has been missing for San Francisco, including his timing, accuracy and adjustments on offense.
Before going down with the injury, Purdy had a 65.8% completion rate for 586 yards and four touchdowns.
September 28, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs the football against Jacksonville Jaguars linebacker Devin Lloyd (0) during the second quarter at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images
The Arizona native returns to face his home team, hailing from Queen Creek and graduating from Perry High School. While Valley fans’ loyalty has always been to the Cardinals, they’ve consistently welcomed him back with excitement, especially given how far his career has come.
Arizona has dealt with its share of injuries and will need to rely heavily on its depth against San Francisco, with Kyler Murray and Marvin Harrison Jr. sidelined. Without a win against a divisional opponent this season, the Cardinals have another opportunity to secure their first or risk falling further down the standings.
Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) celebrates after throwing a touchdown pass against the Seattle Seahawks during the fourth quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images
The Cardinals and 49ers face off on Sunday, Nov. 16, at 2:05 p.m.
Brock Purdy will return as San Francisco’s starting quarterback Sunday vs. the Arizona Cardinals, HC Kyle Shanahan told the 49ers Game Plan. pic.twitter.com/wxEB5HWgbq
— Adam Schefter (@AdamSchefter) November 13, 2025
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Wendy Lopez is a reporter for Burn City Sports. You can follow her on her X account, @wlopezde
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