GLENDALE – Arizona Cardinals running back James Conner suffered a serious lower body injury in the third quarter of the Week 3 game vs. the San Francisco 49ers. On a second-and-one run, Conner was able to secure the first down, but the tackle contorted the 30-year-old’s top half away from his bottom half, causing his ankle to bend unnatural.
Thank you for reading this post, don't forget to subscribe!Conner immediately reacted to the pain, with his Arizona teammates visually upset from the injury. Details have been sacred, but ESPN’s Josh Weinfuss has a source that stated that Conner’s injury is likely season-ending.
Sep 21, 2025; Santa Clara, California, USA; Medical personal tend to Arizona Cardinals running back James Conner (6) during the second half against the San Francisco 49ers at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images
Weinfuss on Cardinals star running back going down:
The five-year Cardinals running back has been the engine of the offense for the past half decade. His slow start to 2025 seemed to start to turn around, as the amount of touches Conner saw in Week 3 was an encouraging sight. However, the roster will be forced to pivot to its backup option of Trey Benson and Emari Demercado.
Sep 21, 2025; Santa Clara, California, USA; Arizona Cardinals running back James Conner (6) avoids the tackle by. San Francisco 49ers cornerback Deommodore Lenoir (2) during the first half at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images
The injury bug has gotten Arizona good to start the year, losing top players to IR on the defensive side, but now get its first significant loss on the offensive side of the ball. Many Cardinals players have gone on social media to show their support for Conner and will likely dedicate the team’s season to him.
Cardinals QB Kyler Murray reacts to James Conner injury vs. 49ers
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Reporter Tanner Tortorella covers general assignment for Burn City Sports. You can follow him on his X account, @TannerTSports
