GLENDALE – The Arizona Cardinals likely could’ve lost their starting running back for the season. Early in the third quarter, RB James Conner on a 2nd and one converted for the first down but had his top half twisted, while his legs were vulnerable and had a San Francisco 49ers land on the tackle.
Thank you for reading this post, don't forget to subscribe!Conner immediately grabbed his leg and had to be carted off the field. When Fox later showed the replay, the 30-year-old Pro Bowler had his leg bent in a very awkward position.
Arizona Cardinals running back James Conner (6) jukes by Carolina Panthers cornerback Jaycee Horn (8) at State Farm Stadium on Sept 14, 2025.
Cardinals Conner injured vs. 49ers in Week 3:
Conner is one of the toughest players in the league, and him having to be carted off showed the severity of the injury. He is seen as the engine of the offense, getting plenty of touches on the run game and air attack in Sunday’s game vs. the 49ers.
Arizona Cardinals running back James Conner (6) takes the field before their game against the Carolina Panthers at State Farm Stadium on Sept. 14, 2025.
Arizona already had injuries to its top three cornerbacks in last week’s game vs. the Carolina Panthers. Two defensive players were added to the IR, and now, in all likelihood, Conner will be added to that list with a significant leg injury.
Cardinals’ offensive line to be tested by 49ers’ front seven in Week 3
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Reporter Tanner Tortorella covers general assignment for Burn City Sports. You can follow him on his X account, @TannerTSports
