GLENDLAE – ESPN’s NFL reporter Jeremy Fowler has reported that Arizona Cardinals two-time Pro Bowl quarterback Kyler Murray will miss Sunday’s game vs. the Indianapolis Colts due to a foot injury. Backup quarterback Jacoby Brissett is expected to make his first start for Arizona against his former team Indianapolis, which he played with for four seasons.
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Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) against the Seattle Seahawks at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images
Brissett to start over injured Murray:
Week 6 will be Murray’s first missed game since returning -from his ACL tear back in 2023. The 28-year-old had played in 30 straight game the longest streak since he entering the league. The foot injury Murray suffered in Week 5 happened in the third quarter off a botched snap that hit his face. He tried to jump after the fumble, and proceeded to injury himself on the play and had to exit the game for two offensive plays.
Aug 2, 2025; Glendale, AZ, USA; Arizona Cardinals quarterback Kyler Murray (1) and Jacoby Brissett (7) during the Red and White practice in training camp at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images
Brissett will get his first start with the Cardinals. He has a 19-34 career record, with his latest stint being with the New England Patriots last season. In 5 starts, the 32-year-old averaged 139.2 passing yards per game with two touchdowns and two turnovers. Brissett is a game manager and will be put in a tough position against a 4-1 Colts squad that has dominated opponents this season.
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Reporter Tanner Tortorella covers general assignment for Burn City Sports. You can follow him on his X account, @TannerTSports
