GLENDALE – The Arizona Cardinals and San Francisco 49ers have been banged up to start the 2025 season. The two teams submitted their latest injury report ahead of their Week 3 matchup, having key players on both sides questionable to compete. Arizona will likely be without two of its top cornerbacks, with Garrett Williams on IR and rookie Will Johnson being doubtful on the injury report.
Thank you for reading this post, don't forget to subscribe!Starting tackle Paris Johnson Jr. is questionable with a knee issue, and fellow offensive lineman Will Hernandez is ramping up from his return from his ACL injury from last year.

Arizona Cardinals offensive tackle Paris Johnson Jr. (70) is introduced before playing against the New York Jets at State Farm Stadium in Glendale on Nov. 10, 2024. © Michael Chow/The Republic / USA TODAY NETWORK via Imagn Images
The 49ers will be without two critical offensive players, quarterback Brock Purdy and wide receiver Jauan Jennings. The duo are battling shoulder and lower leg injuries. Reports have indicated that San Francisco will go with backup Mac Jones. Purdy made a push to start Sunday’s game but couldn’t recover in time.
Full Cardinals-49ers injury report:
- Cardinals:
- CB Will Johnson (Groin) – doubtful
- OL Will Hernandez (Knee) – Questionable
- OL Paris Johnson Jr. (Knee) – Questionable
- CB Max Melton (Knee) – Questionable
- TE Tip Reiman (Foot) – Questionable
- 49ers:
- G Spencer Burford (Knee) Out
- WR Jordan Watkins (Calf) – Out
- G Connor Colby (Groin) – Questionable
- WR Jauan Jennings (Ankle/Shoulder) – Out
- QB – Brock Purdy (Toe/Left Shoulder) – Out

Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) looks on after losing to the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images
Each team is undefeated through the first two weeks and are eyeing to keep their hot start to the season. The 49ers will be missing key players on the offensive side, while the Cardinals’ secondary will be bare due to being decimated by injuries last week.
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Reporter Tanner Tortorella covers general assignment for Burn City Sports. You can follow him on his X account, @TannerTSports
