GLENDALE – Having already proved once that the outside expectations do not matter, the Arizona Cardinals get another opportunity to prove the league wrong when they take on the Seattle Seahawks in Week 2.
Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals linebacker Jordan Burch (52) tackles Seattle Seahawks running back Zach Charbonnet (26) in the third quarter at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images
After stunning the Los Angeles Chargers 26-14 in Week 1, Arizona returns home for a matchup with the defending Super Bowl champion Seattle Seahawks. This time, the Cardinals have even more reason to believe another upset is possible.
Arizona Cardinals receiver Marvin Harrison Jr. (18) celebrates a touchdown by teammate Emari Demercado (31) to tie the game at 20-20 against the Seattle Seahawks at State Farm Stadium in Glendale on Sept. 25, 2025. © Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images
One of the biggest differences is at quarterback. Seattle will be without Sam Darnold, who suffered a glute injury in the season opener and is expected to miss Week 2. Drew Lock will take over, and that matters against a Cardinals defense that just held the Chargers to 14 points. But Arizona’s biggest reason for optimism might be its own quarterback. Jacoby Brissett wasn’t simply efficient against Los Angeles. He played like a quarterback who understood exactly what the moment required. He threw for 277 yards and a touchdown without an interception and finished Week 1 with an 86.1 PFF grade, the highest among qualified quarterbacks.
Jacoby Brissett finished with the highest PFF grade among quarterbacks in Week 1. pic.twitter.com/rTUwSkGsus
— Kyle Odegard (@Kyle_Odegard) September 15, 2026
Then there is Trey McBride. The Cardinals’ star tight end caught nine passes for 95 yards and a touchdown, immediately looking like the centerpiece of Mike LaFleur’s offense. Arizona isn’t entering Week 2 hoping Week 1 was a fluke. The Cardinals have already shown they can play complementary football: Brissett can operate the offense, McBride can create mismatches, the defense can make stops, and special teams can change the game. Now the Cardinals get their home crowd, a quarterback advantage on paper, and the confidence of knowing they can beat a team nobody is expecting them to beat.
Arizona Cardinals receiver Marvin Harrison Jr. (18) catches a touchdown pass as Seattle Seahawks cornerback Devon Witherspoon (21) defends at State Farm Stadium in Glendale on Sept. 25, 2025. © Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images
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Reporter Benjamin Bliklen covers the Arizona Diamondbacks, Arizona Cardinals, and Phoenix Suns for Burn City Sports. You can follow him on his X account, @BenBliklenÂ
