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The Arizona Cardinals (3-10) prepare to face NFC leaders, the San Francisco 49ers (10-3), post-bye week.
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Five 49ers players with ties to Arizona will play at the Cardinals' home turf.
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Quarterback Brock Purdy, a native of Queen Creek, played for Perry High School before joining the NFL.
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Wide receiver Brandon Aiyuk transferred from Sierra College to Arizona State University, later drafted by the 49ers.
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Linebacker Randy Gregory played for Arizona Western College before a successful NFL career with multiple teams.
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Tucson native Demetrius Flannigan-Fowles, a product of Mountain View High School, returns home playing for the 49ers.
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