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The Arizona Cardinals (1-2) are facing the San Francisco 49ers (3-0) on the road.
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Key 49ers players on the injury report include Deebo Samuel, Brandon Aiyuk, and Dre Greenlaw.
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The 49ers have a potent offense, ranking third in the NFL, averaging 30 points per game.
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Quarterback Brock Purdy had a strong connection with Aiyuk in the first two games of the season.
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Deebo Samuel stepped up in Aiyuk's absence and had a productive game against the New York Giants.
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The wide receiver depth for the 49ers may be a concern if Samuel and Aiyuk are unable to play, affecting their passing game.
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